The average bus between Baltimore and Buffalo takes 13h 36m and the fastest bus takes 11h 20m. The bus service runs several times per day from Baltimore to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Baltimore and Buffalo. The earliest departure is at 1:10 AM at night, and the last departure from Baltimore is at 8:55 PM which arrives into Buffalo at 8:15 AM. All services require a transfer, and take on average 13h 36m. The schedules shown below are for the next available departures.

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11h 20m • 1 change
Want to know about travelling from Baltimore to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Baltimore to Buffalo. However, there are services departing from Baltimore station and arriving at Buffalo station via Newark Penn Station station. The journey, including transfers, takes approximately 13h 36m.
Baltimore to Buffalo bus services, operated by Greyhound USA, depart from Baltimore Downtown Bus Station.
Baltimore to Buffalo bus services, operated by Greyhound USA, arrive at Buffalo station.
Book your Baltimore to Buffalo bus tickets online with Greyhound USA and Flixbus USA.
The distance between Baltimore and Buffalo is 442.6 km. The road distance is 938 km.
You can take a bus from Baltimore Downtown Bus Station to Buffalo via Newark Penn Station in around 11h 40m.