The average bus between Afyon and Istanbul takes 8h and the fastest bus takes 7h 25m. There is a bus service every few hours from Afyon to Istanbul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Afyon and Istanbul. The earliest departure is at 12:45 AM at night, and the last departure from Afyon is at 9:30 PM which arrives into Istanbul at 5:50 AM. All services require a transfer at Bursa bus station and take an average of 8h. The schedules shown below are for the next available departures.

7h 30m • 1 change

9h • 1 change

8h • 1 change

7h 59m • 1 change

7h 45m • 1 change

8h 15m • 1 change

8h 30m • 1 change

8h • 1 change

7h 45m • 1 change

8h 15m • 1 change

8h 30m • 1 change

8h • 1 change

7h 45m • 1 change

8h 15m • 1 change

8h 30m • 1 change

8h • 1 change
Want to know about travelling from Afyon to Istanbul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Afyon to Istanbul. However, there are services departing from Afyon station and arriving at Istanbul station via Bursa bus station station. The journey, including transfers, takes approximately 8h.
Afyon to Istanbul bus services, operated by Kamil Koç, depart from Afyon bus station.
Afyon to Istanbul bus services, operated by Kamil Koç, arrive at Esenler Otogar station.
Book your Afyon to Istanbul bus tickets online with Kamil Koç, Pamukkale Turizm and 3 other operators.
The distance between Afyon and Istanbul is 280.8 km. The road distance is 436 km.
You can take a bus from Afyon bus station to Esenler Otogar via Bursa bus station and Bursa in around 6h 1m.