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From Siena bus to Pisa Centrale then train to La Spezia Centrale. 2hrs 40min 71€. From Siena train to Empoli, train to Pisa Centrale, then train to La Spezia Centrale. 3hrs 00min 23€. From Siena line 145 bus to Pisa Centrale then train to La Spezia Centrale. 4hrs 35min 38€. From Siena drive to La Spezia. 2hrs 24min 34€.

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