From Pioneer Square tram to Seattle airport, fly to St. Louis airport, then train to St. Louis. 6hrs 53min $214. From Seattle, WA train to Chicago, IL then train to St. Louis, MO. 2days 02hrs $233. From Seattle, WA train to Portland, OR, line 1337 bus to Salt Lake City, Bus to Denver, then Bus to St Louis. 2days 06hrs $401. From Seattle drive to St. Louis. 34hrs 46min $269.