From Pioneer Sq Stn & Pioneer Sq Stn St tram to Seattle airport, fly to St. Louis airport, then train to St. Louis. 6hrs 57min $214. From Seattle, WA train to Chicago, IL then train to St. Louis, MO. 2days 02hrs $332. From Seattle, WA train to Portland, OR, bus to Salt Lake City, UT, bus to Denver, CO, then bus to St. Louis, MO. 2days 05hrs $484. From Seattle drive to St. Louis. 34hrs 46min $269.