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From Roma Termini train to Genova Piazza Principe then train to Savona. 5hrs 21min 77 €. From Cavour- Ricci bus to Rome, bus to Siena, bus to De Ferrari, bus to Genova Piazza Principe, then train to Savona. 9hrs 25min. From Rome drive to Savona. 5hrs 50min 98 €. From Roma Termini train to Rome airport, fly to Genoa airport, then train to Savona. 3hrs 31min 149 €.