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From Roma Termini train to Genova Piazza Principe then train to Savona. 5hrs 21min 75 €. From Cavour Metro to Rome, bus to Siena, bus to De Ferrari, bus to Genova Piazza Principe, then train to Savona. 8hrs 53min. From Rome drive to Savona. 5hrs 50min 96 €. From Roma Termini train to Rome airport, fly to Genoa airport, then train to Savona. 3hrs 31min 146 €.