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From Roma Termini train to Villa San Giovanni then ferry to Messina Marittima. 6hrs 14min 97 €. From Roma Ostiense train to Messina Centrale. 9hrs 28min 67 €. From Rome bus to Messina. 9hrs 33min 47 €. From Ara Coeli- Piazza Venezia line 492 bus to Rome, bus to Villa San Giovanni, Car ferry to San Francesco, then line 28 tram to Municipio. 10hrs 41min. From Rome rideshare to Messina. 7hrs 59min 35 €. From Rome drive to Messina. 8hrs 27min 134 €. From Roma Termini train to Rome airport, fly to Reggio Calabria airport, bus to Reggio di Calabria, then ferry to Messina. 6hrs 05min 83 €. From Roma Termini train to Rome airport, fly to Catania airport, bus to Catania Centrale, then train to Messina. 6hrs 41min 70 €. From Roma Termini train to Napoli Centrale, bus to Naples airport, fly to Catania airport, bus to Catania Centrale, then train to Messina. 6hrs 30min 124 €. From Roma Termini train to Rome airport, fly to Palermo airport, train to Palermo Centrale, then train to Messina. 9hrs 03min 90 €.