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From Roma Termini train to Villa San Giovanni then ferry to Messina Marittima. 6hrs 14min 93 €. From Roma Ostiense train to Messina Centrale. 9hrs 29min 68 €. From Rome bus to Messina. 9hrs 33min 45 €. From Ara Coeli- Piazza Venezia line 492 bus to Rome, bus to Villa San Giovanni, Car ferry to San Francesco, then line 28 tram to Municipio. 10hrs 41min. From Rome rideshare to Messina. 7hrs 59min 34 €. From Roma Termini train to Rome airport, fly to Reggio Calabria airport, bus to Reggio di Calabria, then ferry to Messina. 6hrs 05min 85 €. From Roma Termini train to Rome airport, fly to Catania airport, bus to Catania Centrale, then train to Messina. 6hrs 45min 102 €. From Roma Termini train to Napoli Centrale, bus to Naples airport, fly to Catania airport, bus to Catania Centrale, then train to Messina. 6hrs 34min 133 €. From Roma Termini train to Rome airport, fly to Palermo airport, train to Palermo Centrale, then train to Messina. 8hrs 55min 111 €.