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From Praha hl.n. train to Cheb, train to Kirchenlaibach, then train to Bayreuth Hbf. 5hrs 12min 590 Kč. From Prague Florenc bus to Cheb, train to Marktredwitz, then train to Bayreuth Hbf. 6hrs 18min 738 Kč. From Praha, ÚAN Florenc bus to Nurenberg then bus to Bayreuth. 6hrs 46min 1 371 Kč. From Prague drive to Bayreuth. 3hrs 36min 1 266 Kč.