From Prague airport fly to Munich airport, light rail to München Hbf, train to Nürnberg Hbf, then train to Bayreuth. 5hrs 23min $290. From Prague Ruzyně Airport T1 bus to Cheb, train to Marktredwitz, train to Kirchenlaibach, then train to Bayreuth Hbf. 4hrs 49min $23. From Prague drive to Bayreuth. 2hrs 50min $54.