From Niagara Falls, NY train to Rochester, NY then bus to Ithaca, NY. 4hrs 56min $45. From Niagara Falls drive to Ithaca. 3hrs 16min $23. From Niagara Falls, NY train to Amtrak Station & Dick Road, line 46 bus to Galleria Driveway & Green Parking Entrance, line 32 bus to Buffalo airport, fly to Ithaca airport, then taxi to Ithaca. 7hrs 37min $417.