From Niagara Falls, NY train to Rochester, NY then bus to Ithaca, NY. 4hrs 56min $49. From Portage Road & Portage Rd Transpo Center line 40 bus to Washington Street & South Division Street, bus to Buffalo, NY - Airport, then line 246 bus to Ithaca, NY. 6hrs 20min $34. From Niagara Falls drive to Ithaca. 3hrs 16min $21. From Niagara Falls, NY train to Buffalo, NY, bus to Buffalo airport, fly to Ithaca airport, then taxi to Ithaca. 6hrs 35min $429.