From Milton Keynes Centr. train to Euston, line 205 bus to London Marylebone, then train to High Wycombe. 1hrs 23min £27. From Central Milton Keynes, The Point (Central Milton Keynes The Point H3) bus to Aylesbury, Bus Station (Bus Stn Bay 7) then line 300 bus to High Wycombe, Oxford Street (Bull Lane). 2hrs 11min £9. From Milton Keynes drive to High Wycombe. 1hrs 11min £11.