From Milton Keynes Central train to Euston Bus Station, line 18 bus to London Marylebone, then train to High Wycombe. 1hrs 16min £50. From Central Milton Keynes, The Point (Central Milton Keynes The Point H3) bus to Aylesbury, Bus Station (Bus Stn Bay 7) then line 300 bus to High Wycombe, Frogmoor (viaduct). 2hrs 05min £5. From Milton Keynes taxi to High Wycombe. 48min £117. From Milton Keynes drive to High Wycombe. 48min £7.