From Milano Centrale train to Spiez, train to Interlaken Ost, then train to Grindelwald. 3hrs 54min SFr 73. From Milano center bus to Malpensa Airport T1, bus to Domodossola, train to Iselle transito, then drive to Grindelwald. 6hrs 39min SFr 58. From Milan drive to Grindelwald. 3hrs 31min SFr 58.