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From Milano Centrale train to Spiez, train to Interlaken Ost, then train to Grindelwald. 3hrs 52min 64 €. From Milano center bus to Malpensa Airport T1, bus to Domodossola, train to Brig, train to Spiez, train to Interlaken Ost, then bus to Grindelwald. 5hrs 59min 63 €. From Milan drive to Grindelwald. 4hrs 12min 56 €.