From Milano Centrale train to Brig, train to Spiez, train to Interlaken Ost, then train to Grindelwald. 4hrs 09min 57€. From Milano center bus to Malpensa Airport T1, bus to Domodossola, train to Brig, train to Spiez, train to Interlaken West, Bahnhof, then bus to Grindelwald, Bahnhof. 6hrs 53min 62€. From Milan drive to Grindelwald. 3hrs 31min 53€.