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From Duomo Metro to Milano Centrale, train to Spiez, train to Interlaken Ost, then train to Grindelwald. 4hrs 00min 82 €. From Milano center bus to Malpensa Airport T1, bus to Domodossola, train to Spiez, train to Interlaken Ost, then bus to Grindelwald. 6hrs 22min 65 €. From Milan drive to Grindelwald. 4hrs 16min 54 €.