From Se 1St@Se 1 Av line 195 bus to Fort Lauderdale, FL - Hollywood Denny's, bus to Fort Myers, FL - McDonalds, then taxi to Cape Coral. 4hrs 31min $72. From W Flagler St@Nw 1 Av line 95 bus to Miami North, FL - Golden Glades, bus to Ft Myers, FL, then taxi to Cape Coral. 5hrs 26min $72. From Miami drive to Cape Coral. 2hrs 48min $25.