From Government Center Metrorail to Okeechobee Rd Sta@2005 W Okeechobee, line 73 bus to Hialeah, FL, bus to Fort Myers, FL, then taxi to Cape Coral. 3hrs 28min. From W Flagler St@Nw 1 Av line 95 bus to Miami North, FL - Golden Glades, bus to Ft Myers, FL, then taxi to Cape Coral. 5hrs 18min $72. From Miami drive to Cape Coral. 2hrs 44min $25.