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From Memphis, TN bus to Nashville, TN then bus to Louisville, KY. 8hrs 48min $70. From Second and Exchange line 20 bus to Memphis, TN then bus to Louisville. 11hrs 48min $141. From Memphis drive to Louisville. 6hrs 14min $55. From Second and Jefferson line 20 bus to Memphis airport, fly to Louisville airport, then line 2 bus to Louisville. 7hrs 34min $193. From Second and Jefferson line 20 bus to Memphis airport, fly to Indianapolis airport, bus to Indianapolis, IN, then bus to Louisville. 8hrs 03min $273. From Second and Jefferson line 20 bus to Memphis airport, fly to Covington airport, bus to Covington Transit Center, bus to Government Square Area A, line 11 bus to Cincinnati, OH, then bus to Louisville. 8hrs 41min $332.