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From Madrid Puerta del Sol train to Madrid-Chamartin, train to Ávila, bus to Aveiro, then train to Coimbra-B. 7hrs 30min 61 €. From Madrid Puerta del Sol train to Madrid-Chamartin then train to Coimbra-B. 32hrs 26min 52 €. From Madrid drive to Coimbra. 5hrs 43min 81 €. From Recoletos train to Madrid airport, fly to Porto airport, Metro to Porto(Campanha), then train to Coimbra. 5hrs 29min 58 €. From Recoletos train to Madrid airport, fly to Lisbon airport, Metro to Lisboa Oriente, then train to Coimbra. 6hrs 05min 77 €.