From London Heathrow airport fly to Manchester airport then train to Crewe. 1hrs 53min $104. From London Heathrow airport fly to Leeds Bradford airport, line 757 bus to Leeds, train to Manchester Piccadilly, then train to Crewe. 3hrs 08min $125. From Heathrow Terminals 1-3 train to Paddington Rail Station, line 205 bus to London Euston, then train to Crewe. 2hrs 22min $79. From Heathrow Central Bus Station line 140 bus to Harrow & Wealdstone, train to Northampton, then train to Crewe. 5hrs 05min $67. From London Heathrow drive to Crewe. 2hrs 47min $52.