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From Lecce line 793 bus to Brindisi airport, fly to Palermo airport, then train to Palermo. 7hrs 49min 121 €. From Lecce train to Bari Centrale, train to Bari airport, fly to Palermo airport, then train to Palermo. 6hrs 33min 157 €. From Lecce line 793 bus to Brindisi airport, fly to Trapani airport, then bus to Palermo. 10hrs 55min 112 €. From Lecce bus to Catania FS then bus to Palermo. 12hrs 20min 49 €. From Lecce train to Brindisi, train to Taranto, train to Sibari, train to Castiglione Cosentino, train to Paola, train to Villa San Giovanni, ferry to Messina Centrale, then train to Palermo Centrale. 13hrs 19min 119 €. From Lecce line 350 bus to Taranto then bus to Palermo Politeama. 14hrs 25min 44 €.