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From Lecce train to Via Bastioni San Giorgia, bus to Brindisi airport, fly to Palermo airport, then train to Palermo. 7hrs 28min 135€. From Lecce train to Bari Centrale, train to Bari airport, fly to Palermo airport, then train to Palermo. 6hrs 11min 114€. From Lecce train to Via Bastioni San Giorgia, bus to Brindisi airport, fly to Trapani airport, then bus to Palermo. 10hrs 01min 219€. From Lecce train to Via Bastioni San Giorgia, bus to Brindisi airport, fly to Catania airport, then bus to Palermo. 9hrs 20min 166€. From Lecce bus to Messina FS then bus to Palermo. 11hrs 16min 44€. From Lecce train to Brindisi, train to Taranto, bus to Messina Centrale, then train to Palermo Centrale. 12hrs 59min 82€. From Lecce bus to Taranto, bus to Bivio Cantinella, then bus to Palermo. 13hrs 53min 67€. From Lecce drive to Villa San Giovanni, Car ferry to Rada San Francesco, then drive to Palermo. 8hrs 38min 137€.

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