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From Lecce bus to Catania FS then bus to Palermo. 12hrs 20min 51 €. From Lecce train to Brindisi, train to Taranto, train to Sibari, train to Castiglione Cosentino, train to Paola, train to Villa San Giovanni, Ferry to Messina Centrale, then train to Palermo Centrale. 13hrs 34min 120 €. From Lecce line 350 bus to Taranto then bus to Palermo Politeama. 14hrs 25min 43 €. From Lecce drive to Villa San Giovanni, Ferry to Messina Marittima, then drive to Palermo. 8hrs 10min 124 €. From Lecce line 793 bus to Brindisi airport, fly to Palermo airport, then train to Palermo. 7hrs 49min 103 €. From Lecce train to Bari Centrale, train to Bari airport, fly to Palermo airport, then train to Palermo. 6hrs 33min 153 €. From Lecce line 793 bus to Brindisi airport, fly to Trapani airport, then bus to Palermo. 10hrs 30min 109 €.