From Interlaken West train to Bern, train to Zürich HB, then train to Lugano. 5hrs 09min SFr 117. From Interlaken Ost train to Luzern then train to Lugano. 5hrs 16min SFr 81. From Interlaken, Kursaal line 21 bus to Thun, train to Berne, bus to Bellinzona, then bus to Lugano. 8hrs 28min SFr 127. From Interlaken drive to Lugano. 2hrs 23min SFr 28.