From Fresno airport fly to San Francisco airport, BART to Millbrae Caltrain Station, then Caltrain to Palo Alto. 3hrs 12min $289. From Fresno taxi to Fresno, CA, bus to Santa Clara & Almaden Ave, line 17 bus to San Jose Caltrain Station, then Caltrain to Palo Alto Caltrain Station. 4hrs 31min $62. From Fresno drive to Palo Alto. 3hrs 24min $25.