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From Charlotte Transportation Center bus to Charlotte airport, fly to Roanoke airport, then taxi to Roanoke. 2hrs 46min $261. From Charlotte Transportation Center bus to Charlotte airport, fly to Lynchburg airport, taxi to Lynchburg, VA - Amtrak, then bus to Roanoke. 4hrs 45min $283. From Charlotte, NC bus to Wytheville, VA then bus to Roanoke, VA. 5hrs 27min $46. From Charlotte drive to Roanoke. 3hrs 23min $25.

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